Chemical constituents from Curcuma longa L. and their inhibitory effects of nitric oxide production.

Chemical constituents from Curcuma longa L. and their inhibitory effects of nitric oxide production.

Nat Prod Res. 2017 Jul 20;:1-6

Authors: Yuan T, Zhang C, Qiu C, Xia G, Wang F, Lin B, Li H, Chen L

Abstract

A new bisabolane-type sesquiterpenoid, turmerone Q (1), along with six known compounds (2-7), were isolated from the rhizomes of Curcuma longa L. The structural elucidation of the new compound was conducted using (1)H NMR, (13)C NMR, HSQC, HMBC and NOESY spectroscopic analyses. The absolute configuration of 1 was elucidated by comparison of the experimental and calculated ECD spectra. The anti-inflammatory effects of 1-7 were evaluated through lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 macrophages assays, and compounds 6 and 7 showed potent inhibitory activity against NO production.

PMID: 28726500 [PubMed - as supplied by publisher]