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Synthesis of [(18) O2 ]-curcumin.
J Labelled Comp Radiopharm. 2014 Sep 29;
Authors: Shen X, Yang X, Zhu Y, Liu X, Wen H
Abstract
Curcumin, a pigment isolated from rhizomes of Curcuma longa, is a potent cancer chemopreventive and chemotherapeutic agent and is now evaluated in phase III human clinical trials. This report describes an efficient synthesis of [(18) O2 ]-curcumin. [(18) O2 ]-Curcumin was prepared in three steps from 1-iodo-2-methoxy-4-methylbenzene in an overall yield of 53%.
PMID: 25267481 [PubMed - as supplied by publisher]