High-Doses of Antidepressants Less Risky on Heart Than Initially ThoughtAJMC.com Managed Markets NetworkHigh doses of the antidepressants citalopram (Celexa) and escitalopram (Cipralex, Lexapro) do not appear to carry greater risk of sudden cardiac death than comparable doses of other selective serotonin reuptake inhibitors, according to a new study.