Ward 12

Submitted by admin on Fri, 04/15/2016 - 02:02
Case Slide No.: 
6
Type: 
MARROW CRUSH
Description: 
Shown here is a newcomer to the mix: a trinucleate myeloma cell. It has but one hof. The 6 nuclei of the central 4 myeloma cells exhibit varying degrees of maturation.
Comment: 
Not one of the cyto-logic features observed in this rare case of IgE disease is any different from those encountered in more common isotypes of myeloma. IgE myeloma is a highly aggressive form of the disease. In a comparable case reported in 1999, the M-protein was located in the gammaglobulin fraction. Osteolytic lesions were documented in both skull and inferior pubic arch. A bone marrow study showed that 40% of nucleated cells were abnormal plasma cells. The dominant light-chain was kappa. (Kairemo KJ, Lindberg M, Prytz M. Scand J Clin Lab Invest,1999; 59 (6):451-6 ). Beyond indicating probable neoplasia, a occasional trinucleate plasmacytoid cell in a marrow infiltrated by plasma cells does little to change prognosis.
Slide Image: 
Case Series: 
IgE MYELOMA. CASE 1 
Dr J GREALLY, M62-85
Sequence No.: 
12