Ward 39

Submitted by admin on Fri, 04/15/2016 - 02:02
Case Slide No.: 
10
Type: 
TREPHINE
Description: 
In this final frame of the case, the scant infiltrate is dispersed. For no apparent reason, the author counted 10 myeloma cells in this field What is your count? See comment.
Comment: 
Thus, there are no telling cytologic features which might help distinguish this rare entity from other forms of myeloma. Cytologic differences however do help separate IgM myeloma from IgM lymphoplasmacytic lymphoma (Waldenstrom macroglobulinemia). [See section on WM]. 
In addition, features such as lytic lesions of bone occur in 90% of patients with IgM myeloma and in only 2-10% of those with WM. Renal disease is common in IgM MM, and considered rare in WM. (Referenced in : IgM Myeloma, a distinct entity in the spectrum of B-cell neoplasia. Zarrabi MH, Stark RS, Kane P, et al. In Am J Clin Pathol 75:1-10, 1981).
Slide Image: 
Case Series: 
IgM MYELOMA
Series No.: 
CASE 2
Case No.: 
12